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AI-Powered Clinical Trial Platform

Recruit smarter.
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Trialio is an AI-powered Clinical Trial Pre-Screening Platform built for Australian trial sites — automating participant screening, eligibility scoring, and coordinator workflows so your team stays focused on the candidates who matter most.

Trialio — Live Screening
78
Eligibility Score
James Okafor
Likely Eligible
Criteria Match
60%
Data Complete
25%
Confidence
15%
Synthia is calling…
Voice screening in progress · CARDIO-AUS-2024
Faster participant screening
0%
Coordinator agreement rate
0/7
Always-on AI screening
0 min
Saved per screening call

How Trialio works

From lead arrival to coordinator-ready report — Synthia handles the entire pre-screening journey autonomously, in real time.

1

Lead Arrives

A new participant record is created via intake form or API. They're instantly queued for Synthia's first contact.

2

Synthia Calls

Synthia places an outbound voice call, conducting a structured conversational screening against the trial's criteria.

3

AI Scores Live

The Eligibility Scoring System runs in real time, producing a 0–100 score, traffic light status, and full breakdown.

4

Report Generated

A coordinator-ready report is auto-generated showing all criteria outcomes, Synthia's recommendation, and next steps.

5

Coordinator Reviews

The coordinator reviews the pre-screened lead in seconds — approve, escalate, or request more information.

Built for every role in the trial

Trialio's portal gives coordinators, investigators, and sponsors a unified operating system for participant management.

🎙️

Synthia Voice Screening

Synthia places structured, conversational outbound calls to participants — handling ambiguous answers, safety escalations, and adaptive follow-up questions automatically.

AI Voice
📊

Live Eligibility Scoring

The three-component Eligibility Scoring System produces a 0–100 score, traffic light status (green/orange/red), and full traceability to individual criteria — in real time.

AI Scoring
📋

Auto-Generated Reports

On call completion, a coordinator-ready pre-screen report is produced instantly — showing criteria outcomes, score breakdown, and recommended next action.

Automation
🛡️

Safety Escalation Engine

Hard exclusion criteria immediately zero the eligibility score and surface an urgent escalation card to the coordinator — with the triggering transcript excerpt.

Safety First
📁

Multi-Trial Dashboard

Manage multiple studies simultaneously. Track enrolment progress, pending leads, scheduled calls, and site-level metrics from a single unified view.

Dashboard
⚙️

Trial Configuration

Configure inclusion/exclusion criteria, classify them as hard/soft, assign clinical weights, and map to Synthia's screening questions — without developer involvement.

No-Code Setup

Watch the portal in action

From browsing active studies, to reviewing participants and launching a Synthia call, through to a live safety escalation — every step happens inside one interface.

📋
Studies Dashboard
Scroll and browse active trials
👥
Participants List
Hover and click “Call Now”
📞
Synthia Live Call
Real-time transcript + scoring
⚠️
Safety Escalation
Hard exclusion triggered instantly
app.trialio.co/studies
Studies
Participants
Synthia
Calendar
Dr. AM
AM
Active Studies 4 trials · 3 recruiting
Studies
Participants
Synthia
Calendar
Dr. AM
AM
All Participants 8 leads · 2 live
TE
Tom Eriksson
CARDIO-AUS-2024
LIVE
3:42
Live Transcript
0
Eligibility Score
Calculating…
Synthia speaking…
🚨
Safety Escalation Required
Hard exclusion criterion triggered · Tom Eriksson
URGENT
Score zeroed — hard exclusion
0
CARDIO-AUS-2024 · Phase III
Not Eligible
⚠ Triggered Criterion
Participant confirmed active anticoagulant therapy (Apixaban 5mg) — a hard exclusion criterion for CARDIO-AUS-2024.
“Yes, I take a blood thinner called Apixaban. I’ve been on it since my AF diagnosis.”
📋 Recommended Action
Advise participant they do not meet current criteria. Consider DIAB-CTRL-3 as an alternative. Synthia has been paused pending coordinator review.
Contact Participant
View Full Transcript
S
Synthia
Active  ·  3 simultaneous calls
12
calls today
Live Screening Call
TE
Tom Eriksson
CARDIO-AUS-2024  ·  Question 4 of 8
4:23
Synthia speaking…
Current Question
“Are you currently taking any anticoagulant or blood-thinning medications?”
Outbound Queue — Today
RT
Rebecca Thornton
11:15am
P1
CW
Chen Wei
11:30am
P2
PN
Priya Nair
2:00pm
P3
All systems operational
3 active  ·  5 queued

Meet Synthia

Synthia handles inbound calls, conducts structured pre-screening interviews, and delivers a real-time eligibility score to your coordinator — before a human even picks up the phone. She understands clinical language, applies safety protocols, and works 24/7 so no lead ever goes cold.

<5min Lead to first Synthia contact
0 Safety escalations missed
24/7 Always available to call
100% Criteria coverage per call

Designed for everyone in the trial

Whether you're running the day-to-day or overseeing the science, Trialio delivers value at every level.

Trial Coordinators

Take back your time — let Synthia handle the calls

  • Receive pre-screened leads with eligibility scores already attached
  • Review Synthia's full call transcript before making any decision
  • Act on urgent safety escalations instantly, with context included
  • Spend your time on enrolled participants, not phone screening
  • One dashboard for all your active trials, participants, and documents
  • Significantly accelerate time-to-enrolment at every site
  • Reduce screen failure rates with more consistent pre-screening
  • Real-time visibility into enrolment progress and site performance
  • Built-in safety mechanisms that never miss a hard exclusion
  • Structured data from every screening call for downstream analytics

Built by people who’ve lived the problem

Trialio was designed at the intersection of clinical practice and software engineering — by a Principal Investigator who felt the friction firsthand, and an engineer who built the solution from the ground up.

AM
Dr. Amith Mammoottil
CEO & Founder  ·  GP & Principal Investigator

Amith is a practising GP and experienced clinical trial investigator. Having worked across multiple research sites, he understands exactly where the pre-screening process breaks down — and what it costs coordinators, sponsors, and participants when it does. Trialio is the platform he designed to fix it.

Experienced clinical trial investigator across multiple research sites
GP with direct insight into participant referral and recruitment pathways
Architect of Trialio — product vision, eligibility scoring & safety escalation design
Leads all clinical protocol design and compliance decisions
View LinkedIn
JA
Josin Abraham
Technical Lead  ·  Full-Stack & AI Engineering

Josin is the technical force behind Trialio — bringing the clinical vision to life through robust, production-grade engineering. He built the coordinator portal, the Synthia voice pipeline, and the real-time scoring engine, with an obsessive focus on reliability and workflow clarity for the people using the platform every day.

Full-stack engineering across React, Node.js & Python/ML
Built the Synthia AI voice pipeline and real-time scoring engine
Developed the coordinator portal, document parsing and reporting modules
Leads all infrastructure, security, and deployment decisions
View LinkedIn
🧬
Clinical Trial Investigator Led
Every feature designed and validated by an experienced clinical trial investigator
🇦🇺
Australian-Built
Designed for Australian clinical trial requirements, TGA compliance context & HREC workflows
🔒
Privacy-First
Health data handling built to the Australian Privacy Act 1988 and ICH E6 GCP standards
🔧
Site-Ready
Configurable per-protocol — from screening scripts to document checklists and safety flags

Ready to transform your trial site?

Request a live demo and see how Synthia pre-screens participants in real time — so your coordinators can focus on what matters.

Book a Demo

Talk to the Trialio team

Whether you're a coordinator, sponsor, or just curious — we'd love to show you what Synthia can do for your site.

📍
Address
1/457–459 Elizabeth St
Surry Hills NSW 2010
Australia
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